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Benzene and Aplastic Anemia

Aplastic anemia happens when the bone marrow has no capacity to produce blood cells. The condition can cause individuals to be more prone to infection and bleeding. It can affect anyone of any age, but the highest incidences are noticed in children and among those between the ages of 20 and 25.

People exposed to organic solvents, pesticides, herbicides, paint removers and thinners, and gasoline are at risk of an increased likelihood of developing anemia due to aplastic.

Benzene

Inhaling or absorbing benzene can cause damage to the blood-forming cell of the bone marrow. These cells are the earliest precursors for all blood types of cells. Leukemia and other blood conditions are caused by exposure to benzene.

Acute Myelogenous Leukemia (AML), Myelodysplastic Syndrome (MDS), Paroxysmal Nocturnal Hemoglobinuria (PNH) and Aplastic Anemia can all be caused by exposure to benzene. These illnesses might not be evident until a few years after exposure. Benzene exposure can also lead to other types of cancers and serious damage to the liver, nervous system, and kidneys.

The chemical is present in petroleum-based items such as dyes, gasoline paint thinners and removers, degreasers and plastics, as well as resins, and insecticides. Workers exposed to these products are at risk of developing aplastic aneurism, depending on their genetics as well as other factors such as previous chemotherapy or radiation treatments and autoimmune diseases such as Rheumatoid arthritis.

Aplastic anemia is more prevalent for those who are regularly exposed to benzene and other organic solvents such as toluene, toluene acetone or methanol. This includes locomotive machinists, Bnsf Railway Aplastic Anemia car department workers and those who work in oil refineries, steel plants, fuel service stations, rubber plants, printing presses or tanneries. Firefighters, smokers, alcoholics, and those suffering from chronic illnesses such as HIV and Hepatitis, as well as women who take certain medications during pregnancy, like folic acids, are also at risk.

Exposure

The bone marrow is damaged and is the root cause of this condition. The bone marrow is a part that produces white and red blood cells. Exposure to benzene in the workplace increases the chance of developing this condition. Other risk factors include genetics, previous chemotherapy or radiation treatments, and certain autoimmune disorders, like rheumatoid arthritis. Benzene can be found in petroleum-based products like gasoline, diesel fuel and a few industrial solvents. Engineers, locomotive machinists as well as railroad car department workers are at greater risk of developing this disorder due to repeated exposure to diesel exhaust. The use of organic solvents, insecticides, herbicides, paint thinners or removers and insecticides may increase the risk.

Symptoms

Treatment options for aplasticanemia, which is determined by the severity and your age, include the observation of blood transfusions, blood transfusions as well as medications. The bone marrow, which is a springy tissue found inside the bones is the main source of blood-producing cells known as hematopoietic cells. These stem cells create red blood cells which transport oxygen, white blood cells that fight germs, and platelets which stop bleeding. Severe aplastic aemia is life-threatening, and bnsf railway aplastic anemia requires immediate hospitalization. Transfusions of blood are a great way to boost your red blood cells as well as reduce anemia and fatigue. However repeated blood transfusions may result in iron overload within the body, leading to heart failure or other organ damage. This issue can be cured by taking medications. A stem-cell or bone marrow transplant can help you rebuild your bone marrow's stem cell population. Doctors can acquire stem cells from donors who have blood that is similar to that of the patient. A sibling is the most suitable match, but unrelated donors are also available. Other treatments, for instance, medications that suppress your immune system (immunosuppressants) can decrease the chance of complications with transplants.

Aplastic anemia can be caused by exposure to toxic chemicals such as benzene. Employers who make use of organic chemicals, such as toluene and turpentine are at risk. These solvents are used in cleaning supplies paint thinners, paint cleaners, and disinfectants. Other risk factors include radiation and chemotherapy treatments as well as certain autoimmune diseases, like rheumatoid arthritis, and viral infections like hepatitis and Epstein-Barr virus.

Treatment

For most people the procedure of a blood and bone Marrow transplant- using healthy donor stem cells to replace damaged ones -- is the best treatment option. The ideal donor is a relative close to you, for example, a sibling however if there's no one available, doctors can check the National Marrow Donor Program for potential matches. This is the only way to treat the severe aplastic ahememia.

If you have severe anemia that is aplastic, you may require frequent blood transfusions in order to get enough red blood cells and platelets. They can reduce anemia, fatigue, and treat symptoms like bleeding and easy bruising. Over time, antibodies can be developed against the blood-forming cells. Anti-inflammatory medications are required to prevent the blood from being rejected.

Other risk factors for aplasticanemia include auto-immune disorders, like the lupus and eosinophilic afflictions; infections, including HIV and hepatitis as well as Epstein-Barr virus and certain cancer treatments, such as chemotherapy or radiation therapy. Aplastic anemia can also be found in people with a history of paroxysmal nighttime hemoglobinuria. It is a rare bone marrow disease.

Exposure to benzene can trigger anemia aplastic, especially at high levels of exposure. Benzene is found in industries like maintenance, auto repair and railroad workers. It is also found in industrial solvents like paint thinners and removers.